In 1887, Jack and Eberhardt Maisel founded their family brewery. They set up outside the gates of Bayreuth, laying the foundations for the future of this renowned brewery. During the Great Depression of the 20s Fritz and Andrew, the sons of the founder brothers, took over the running of the family business, it eventually passing wholly to Fritz Maisel in 1936.

In 1955 he was joined by his sons, Hans and Oscar and a major decision: the introduction of a Weiss beer, which initially produced under the name "Champagne-wheat".
Maisel's Weisse has since been a trendsetter for wheat beer in Germany, and Maisel is a recognized specialty brewery whose beers are appreciated worldwide.

In recent years the brewery has passed into the control of the fourth generation family member Jeff Maisel who shares the same ethos and work ethic of his forefathers. The highest craftsmanship and love of their product characterize the breweries beliefs and are evident in the excellent beer it produces.